This year's "supermoon" is expected be up to 14 percent larger and 30 percent brighter than a typical full moon in an event known as "perigree," when the moon is at its closest point to Earth.
CNN said this year's event will occur at 7:32 a.m. Eastern Daylight Time.
However, the moon will be noticeably larger most of Saturday night as well, in case you don't want to stay up all night or wake up that early on Sunday, astronomers said.
The term "supermoon" came out of the 1970s and is often associated with paranoia and fears of impending natural disasters.
But astronomers say such claims have zero scientific backing.
The US Geological Survey says there is no connection between the supermoon and earthquakes, and there have been no studies linking the moon with human health and behavior.
Pregnant women hoping the supermoon will trigger labor shouldn't hold their breath either. A 2001 study found no noticeable links between births and moon activity.