Netflix and Pinterest restored service by Saturday afternoon, the Associated Press reported.
Instagram used Facebook to post a message about the outage, explaining it was working to restore service.
CNN reported people were still taking to Twitter and Facebook to complain that Instagram, based in northern Virginia, had gone "dark."
The current incidents come just over a week after a massive Twitter outage on June 21, its largest since October 2011.
At least 12 people died and nearly 4 million homes across the Midwest and beyond lost power after fierce thunderstorms struck the region Friday evening, Fox News reported.
The storms brought high winds some 80 miles per hour to Indiana, Ohio, West Virginia, Washington and Virginia, wiping out power and leaving record breaking temperatures in its wake.
Meanwhile, Virginia, West Virginia and Ohio have all declared a state of emergency, according to Fox News.