Jennifer Lawrence, 22, who plays a feisty young widow in Silver Linings Playbook, was named best actress and David O. Russell picked up the best directing honor on Saturday.
Lawrence and Russell are also in the running for Oscars on Sunday, where Silver Linings Playbook is nominated for Best Picture.
"When you make a film from the heart, there is no such thing as genre. They are just real people, and if it's funny in or of itself, that's what happens and that's what my whole cast taught me," Russell said in accepting his award.
Amour, about an elderly couple coping with the effects of the wife's debilitating stroke, won the Best Foreign Film award on Saturday, strengthening its march toward expected Oscar success on Sunday.
The Independent Spirit Awards are handed out by the Los Angeles-based non-profit group Film Independent and are widely considered the top honors for low-budget and art house movies in the United States.
The ceremony, held in a tent on California's Santa Monica beach, are a more laid-back affair than the formal and glitzy Academy Awards ceremony. Bruce Willis, Salma Hayek, Jeremy Renner, Daniel Radcliffe, Amy Poehler and other celebrities were treated to a casual lunch.
Here's a list of Saturday night's winners:
BEST FEATURE Silver Linings Playbook
BEST FEMALE LEAD Jennifer Lawrence, Silver Linings Playbook
BEST MALE LEAD John Hawkes, The Sessions
BEST SUPPORTING FEMALE Helen Hunt, The Sessions
BEST SUPPORTING MALE Matthew McConaughey, Magic Mike
BEST DIRECTOR David O. Russell, Silver Linings Playbook
BEST DOCUMENTARY The Invisible War
BEST FOREIGN FILM Amour
BEST FIRST FEATURE (Award given to the director and producer) The Perks of Being a Wallflower
BEST SCREENPLAY David O. Russell, Silver Linings Playbook
BEST FIRST SCREENPLAY Derek Connolly, Safety Not Guaranteed
BEST CINEMATOGRAPHY Ben Richardson, Beasts of the Southern Wild