Details remain sketchy but the shooting left two men and a woman dead as well as the shooter.
Three state troopers were also injured after the shootout in which the gunman fired at the police car, said the Associated Press.
It is still unclear as to why the shooting took place.
The shooting happened at the same time that the National Rifle Association held a press conference in response to the Sandy Hook shooting which left 20 children and six adults dead.
GlobalPost reported that the NRA's executive vice president, Wayne LaPierre, told reporters that violent video games and mental illness were the likely causes of the second deadliest mass shooting in US history.
He called for a national database of mentally ill people to ensure that they could not get guns.
LaPierre also said that schools should have armed guards.
The Pennsylvania shooting occurred in the Frankstown Township in Blair county, 100 miles east of Pittsburgh.