The Taliban-linked suicide bombers detonated two cars bombs at the main gate of the air base at dawn with follow-up attackers killed in a gunfight.
The second wave of attackers attempted to rush the gates of the compound but were killed by helicopters and Afghan security.
"Coalition forces at the air base successfully defended it, a gunbattle took place and I can confirm that coalition air force were involved," said Martin Crighton, spokesman for the NATO-led coalition, reported the Guardian.
"According to our operational reporting at least one member of the ANSF [Afghan national security forces] was killed and others were wounded."
Though no NATO soldiers were killed, it is still unclear whether any were injured during the blast or ensuing gun battle.
One civilian was killed as he attempted to cross the street near the blast.
Voice of America reported that it was the second attack on the Jalalabad air base this year
It is the third major attack against a joint NATO-Afghan air base since September, when militants attacked Bagram air base destroying a helicopter and killing three, reported GlobalPost.
Also in September, Taliban militants entered a British-US base in Helmand province, killing two marines and destroying six jets.
In October, a suicide bomber blew himself up at a gate of a NATO-Afghan base in Paktia province, wounding several Afghan and NATO troops, said Voice of America.
Jalalabad has been the scene of numerous attacks given its proximity to Pakistan, where it is believed that Taliban fighters take shelter.